![]() ![]() Rebound to normal leukocyte levels follows onset within 2 to 3 days. Maximal white blood cell depression occurs within 2 to 4 days of initiation of therapy. 1,2,3 Leukopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count. Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy. The use of SILVADENE Cream 1% (silver sulfadiazine) in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur. However, the incidence of clinically reported fungal superinfection is low. If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Store at room temperature away from moisture and heat.Results of In Vitro Testing with SILVADENE ® Cream 1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species ![]() Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Your symptoms may improve before the infection is completely cleared. Use this medicine for the full prescribed length of time. ![]() Your kidney function may also need to be tested. While using Thermazene, you may need frequent blood tests. Treated skin areas can be left uncovered, or you may use a gauze bandage if directed by your doctor. Burn wounds must be kept covered with this medicine at all times. Silver sulfadiazine cream is usually applied 1 or 2 times daily. Reapply the cream after bathing or water therapy. If needed, apply more cream to replace any medicine that has come off on bandages, clothing, or bed linens. This medicine should be applied in a layer about one 16th (1/16) of an inch thick, or 1.6 millimeters. Apply enough silver sulfadiazine to cover the affected area evenly. Take care to keep the treatment area as clean as possible to prevent further infection.Ĭlean the area to be treated as directed by your doctor. ![]() The person applying silver sulfadiazine to burn wounds should wear sterile disposable gloves. Wash your hands before and after applying silver sulfadiazine cream. Do not use Thermazene in larger or smaller amounts or for longer than recommended. You may report side effects to FDA at 1-80.įollow all directions on your prescription label. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. Severe skin reaction-fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Liver problems- nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes) or Kidney problems-red or pink urine, little or no urinating, swelling, rapid weight gain Pale or yellowed skin, dark colored urine, fever, confusion or weakness Sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing Įasy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin Thermazene may cause serious side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat.Īlthough the risk of serious side effects is low when silver sulfadiazine is applied to the skin, side effects can occur if the medicine is absorbed into your bloodstream. ![]()
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